Synthesis of pyrazolopyrimidinones as sildenafil derivatives and sclerotigeninopen access
- Authors
- Heo, Hoon Gu; Yu, Jin; Jillella, Raveendra; Oh, Chang Ho
- Issue Date
- Jul-2018
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- n-Heteropolycycle; pyrazolopyrimidinone; quinazolinone; sildenafil
- Citation
- SYNTHETIC COMMUNICATIONS, v.48, no.13, pp.1678 - 1687
- Indexed
- SCIE
SCOPUS
- Journal Title
- SYNTHETIC COMMUNICATIONS
- Volume
- 48
- Number
- 13
- Start Page
- 1678
- End Page
- 1687
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149699
- DOI
- 10.1080/00397911.2018.1459720
- ISSN
- 0039-7911
- Abstract
- A series of novel pyrazolo pyrimidinone derivatives (3(a-d), 4(a-d), and 6(a-d)) was synthesized from various pyrazolo amides (2a-d) which are synthesized by the reaction between ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) and various lithium amides. In addition, we also described the synthesis of sclerotigenin drug molecule which has quinazoline moiety from simple 2-nitro benzoic acid with high yields.
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