Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy
- Authors
- Chang, Ji Hyun; Shin, Kyung Hwan; Ahn, Seung Do; Park, Hae Jin; Chie, Eui Kyu; Kim, Jin Ho; Kim, Su Ssan; Kim, Yong Bae; Park, Won; Kim, Yeon-Joo; Shin, Hyun Soo; Kim, Jin Hee; Lee, Sun Young; Kim, Kyubo; Park, Kyung Ran; Jeong, Bae Kwon; Kim, Ja Young; Kim, Suzy
- Issue Date
- Jun-2018
- Publisher
- SPRINGER
- Keywords
- Breast cancer; Post-mastectomy radiation therapy; Chest wall recurrence risk factor; Chest wall irradiation; 1-3 positive nodes
- Citation
- BREAST CANCER RESEARCH AND TREATMENT, v.169, no.3, pp.507 - 512
- Indexed
- SCIE
SCOPUS
- Journal Title
- BREAST CANCER RESEARCH AND TREATMENT
- Volume
- 169
- Number
- 3
- Start Page
- 507
- End Page
- 512
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149961
- DOI
- 10.1007/s10549-018-4707-0
- ISSN
- 0167-6806
- Abstract
- Purpose In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). Methods The data from the patients participating in two South Korean multi-institutional studies (KROG 14-22; N = 1842 and KROG 14-23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. Results The median follow-up time was 72.2 months (range 0.8-125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. Conclusions The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.
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