Expression of Aquaporins mRNAs in Patients with Otitis Media
- Authors
- Jung, Su Young; Kim, Sung Su; Kim, Young Il; Kim, Hyung-Sik; Kim, Sang Hoon; Yeo, Seung Geun
- Issue Date
- Apr-2018
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Aquaporin; otitis media; middle ear; otitis media with effusion; chronic suppurative otitis media; cholesteatoma
- Citation
- ACTA OTO-LARYNGOLOGICA, v.138, no.8, pp.701 - 707
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA OTO-LARYNGOLOGICA
- Volume
- 138
- Number
- 8
- Start Page
- 701
- End Page
- 707
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150186
- DOI
- 10.1080/00016489.2018.1447685
- ISSN
- 0001-6489
- Abstract
- Objective: This study analyzed the associations between measured levels of aquaporin (AQP) mRNAs and clinical manifestations in patients with various types of otitis media (OM). Methods: AQP1, 2, 3, 4, 5, 6, 8, and 10 mRNA levels were assayed by real-time PCR from 57 patients with chronic otitis media (COM), 24 patients with cholesteatomatous otitis media (choleOM), and 82 patients with otitis media with effusion (OME). The relationships of these mRNA levels with the presence of bacteria, the type of hearing loss, and clinical manifestations of OM types were evaluated. Results: All eight AQP mRNAs were expressed in inflammatory tissue, chole matrix, and effusion fluid obtained from all 163 patients with OM. The levels in OME of AQP2, 4, 6, and 10 mRNA; and the levels in choleOM of AQP1, 3, 4, and 10 mRNA were elevated significantly compared to the corresponding levels in COM (p <.05). The expression level of AQP8 mRNA did not differ among OM types. Among samples positive for bacterial culture, AQP1 mRNA was significantly higher in OME than in COM and choleOM, AQP5 mRNA was significantly lower in OME than in COM and choleOM, and AQP10 mRNA was significantly higher in OME and choleOM than in COM (p <.05). Conclusions: The levels of expression of AQP mRNA are associated with the pathophysiology of OM.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 교육협력지원교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150186)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.