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Scaffolding Protein RanBPM and Its Interactions in Diverse Signaling Pathways in Health and Disease

Authors
Das, SoumyadipHaq, SabaRamakrishna, Suresh
Issue Date
Apr-2018
Publisher
DISCOVERY MEDICINE
Citation
DISCOVERY MEDICINE, v.25, no.138, pp.177 - 194
Indexed
SCIE
SCOPUS
Journal Title
DISCOVERY MEDICINE
Volume
25
Number
138
Start Page
177
End Page
194
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150273
ISSN
1539-6509
Abstract
Ran-binding protein in the microtubule-organizing center (RanBPM) is an evolutionarily conserved, nucleocytoplasmic scaffolding protein involved in various cellular processes and several signal transduction pathways. RanBPM has a crucial role in mediating disease pathology by interacting with diverse proteins to regulate their functions. Previously, we compiled diverse cellular functions of RanBPM. Since then the functions of RanBPM have increased exponentially. In this article, we have updated the functions of RanBPM through its manifold interactions that have been investigated to date, according to their roles in protein stability, transcriptional activity, cellular development, neurobiology, and the cell cycle. Our review provides a complete guide on RanBPM interactors, the physiological role of RanBPM in cellular functions, and potential applications in disease therapeutics.
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GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING (DEPARTMENT OF BIOMEDICAL SCIENCE)
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