Asymptomatic Middle East Respiratory Syndrome coronavirus infection using a serologic survey in Koreaopen access
- Authors
- Song, Yeong-Jun; Yang, Jeong-Sun; Yoon, Hee Jung; Nam, Hae-Sung; Lee, Soon Young; Cheong, Hae-Kwan; Park, Woo-Jung; Park, Sung Han; Choi, Bo Youl; Kim, Sung Soon; Ki, Moran
- Issue Date
- Apr-2018
- Publisher
- KOREAN SOC EPIDEMIOLOGY
- Keywords
- Asymptomatic infection; Epidemiology; Middle East Respiratory Syndrome coronavirus; Nosocomial infections; Outbreak; Enzyme-linked immunespecific assay
- Citation
- EPIDEMIOLOGY AND HEALTH, v.40, pp.1 - 6
- Indexed
- SCOPUS
KCI
- Journal Title
- EPIDEMIOLOGY AND HEALTH
- Volume
- 40
- Start Page
- 1
- End Page
- 6
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150302
- DOI
- 10.4178/epih.e2018014
- ISSN
- 1225-3596
- Abstract
- OBJECTIVES
The rates of asymptomatic infection with Middle East Respiratory Syndrome (MERS) coronavirus vary. A serologic study was conducted to determine the asymptomatic MERS infection rate in healthcare workers and non-healthcare workers by exposure status.
METHODS
Study participants were selected from contacts of MERS patients based on a priority system in 4 regions strongly affected by the 2015 MERS outbreak. A sero-epidemiological survey was performed in 1,610 contacts (average duration from exposure to test, 4.8 months), and the collected sera were tested using an enzyme-linked immunespecific assay (ELISA), immunofluorescence assay (IFA), and plaque reduction neutralization antibody test (PRNT). Among the 1,610 contacts, there were 7 ELISA-positive cases, of which 1 exhibited positive IFA and PRNT results.
RESULTS
The asymptomatic infection rate was 0.060% (95% confidence interval, 0.002 to 0.346). The asymptomatic MERS case was a patient who had been hospitalized with patient zero on the same floor of the hospital at the same time. The case was quarantined at home for 2 weeks after discharge, and had underlying diseases, including hypertension, angina, and degenerative arthritis.
CONCLUSIONS
The asymptomatic infection was acquired via healthcare-associated transmission. Thus, it is necessary to extend serologic studies to include inpatient contacts who have no symptoms.
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