Prognostic Impact of Lymphocyte Subpopulations in Peripheral Blood after Hematopoietic Stem Cell Transplantation for Hematologic Malignanciesopen access
- Authors
- Park, Sang Hyuk; Park, Chan-Jeoung; Park, Borae G.; Bae, Mi-Hyun; Kim, Bo-Hyun; Cho, Young-Uk; Jang, Seongsoo; Park, Ae-Ja; Kim, Dae-Young; Lee, Jung-Hee; Lee, Je-Hwan; Lee, Kyoo-Hyung
- Issue Date
- Mar-2018
- Publisher
- WILEY
- Keywords
- hematologic malignancies; hematopoietic stem cell transplantation; lymphocyte subpopulations; peripheral blood; prognosis
- Citation
- CYTOMETRY PART B-CLINICAL CYTOMETRY, v.94, no.2, pp.270 - 280
- Indexed
- SCIE
SCOPUS
- Journal Title
- CYTOMETRY PART B-CLINICAL CYTOMETRY
- Volume
- 94
- Number
- 2
- Start Page
- 270
- End Page
- 280
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150340
- DOI
- 10.1002/cyto.b.21510
- ISSN
- 1552-4949
- Abstract
- BackgroundWe prospectively evaluated prognostic value of lymphocyte subpopulations in peripheral blood of allogeneic hematopoietic stem cell transplant (HSCT) recipients.
Methods113 allogeneic HSCT (47 sibling matched, 37 unrelated matched, 29 haploidentical)-performed patients diagnosed as AML (n=66), ALL (n=28), and MDS (n=19) were prospectively enrolled. 14 lymphocyte subpopulations were quantified by flow cytometry of PB at specific time-points after HSCT, and their prognostic impacts were analyzed.
ResultsAt 1, 2, and 3months post-HSCT, significant adverse impact on overall survival (OS) and/or event free survival (EFS) was exhibited by low levels of natural killer (NK) cells (32 and 90/mu L at 1 and 2months on OS and EFS); regulatory T cells (1/mu L) on EFS at 2months; and B cells (19 and 92/mu L for OS and EFS at 3months). At 12months, low levels of T cells (1180/mu L), helper/inducer (H/I) T cells (250/mu L), cytotoxic/suppressor (C/S) T cells (541/mu L), and NK cells (138/mu L) were associated with significantly higher risk of relapse. Low levels of T cells (879/mu L) and C/S T cells (541/mu L), and high level of naive thymic T cells (˃115/mu L) showed a significant association with poor OS; low levels of C/S T cells (541/mu L) and NK cells (138/mu L) showed a significant adverse impact on EFS.
ConclusionsLow levels of NK cells, regulatory T cells, and B cells at early stage post-HSCT are adverse prognostic indicators. At late stage, low levels of T cells and their subpopulations, NK cells, and high level of naive thymic T cells are adverse prognostic indicators.
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