HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions
- Authors
- Ryu, Incheol; Park, Yeonkyoung; Seo, Jwa-Won; Park, Ok Hyun; Ha, Hongseok; Nam, Jin-Wu; Kim, Yoon Ki
- Issue Date
- Feb-2019
- Publisher
- FEDERATION AMER SOC EXP BIOL
- Keywords
- mRNA stability; 3UTR; polyadenylation signal; UVC
- Citation
- FASEB JOURNAL, v.33, no.2, pp.2680 - 2693
- Indexed
- SCIE
SCOPUS
- Journal Title
- FASEB JOURNAL
- Volume
- 33
- Number
- 2
- Start Page
- 2680
- End Page
- 2693
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15054
- DOI
- 10.1096/fj.201800431R
- ISSN
- 0892-6638
- Abstract
- All metazoan mRNAs have a poly(A) tail at the 3′ end with the exception of replication-dependent histone (RDH) mRNAs, which end in a highly conserved stem-loop (SL) structure. However, a subset of RDH mRNAs are reported to be polyadenylated under physiologic conditions. The molecular details of the biogenesis of polyadenylated RDH [poly(A)+ RDH] mRNAs remain unknown. In this study, our genome-wide analyses reveal that puromycin treatment or UVC irradiation stabilizes poly(A)+ RDH mRNAs, relative to canonical RDH mRNAs, which end in an SL structure. We demonstrate that the stabilization of poly(A)+ RDH mRNAs occurs in a translation-independent manner and is regulated via human antigen R (HuR) binding to the extended 3′ UTR under stress conditions. Our data suggest that HuR regulates the expression of poly(A)+ RDH mRNAs.—Ryu, I., Park, Y., Seo, J.-W., Park, O. H., Ha, H., Nam, J.-W., Kim, Y. K. HuR stabilizes a polyadenylated form of replication-dependent histone mRNAs under stress conditions. FASEB J. 33, 2680–2693 (2019). www.fasebj.org
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