Prevalence and Associated Factors for Non-adherence in Patients with Rheumatoid Arthritisopen access
- Authors
- Kim, Dam; Choi, Ji-Young; Cho, Soo-Kyung; Choi, Chan-Bum; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Sung, Yoon-Kyoung
- Issue Date
- Jan-2018
- Publisher
- KOREAN COLL RHEUMATOLOGY
- Keywords
- Medication adherence; Arthritis; rheumatoid; Prevalence
- Citation
- JOURNAL OF RHEUMATIC DISEASES (대한류마티스학회지), v.25, no.1, pp.47 - 57
- Indexed
- KCI
- Journal Title
- JOURNAL OF RHEUMATIC DISEASES (대한류마티스학회지)
- Volume
- 25
- Number
- 1
- Start Page
- 47
- End Page
- 57
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150671
- DOI
- 10.4078/jrd.2018.25.1.47
- ISSN
- 2093-940X
- Abstract
- Objective
To estimate the prevalence of non-adherence to rheumatoid arthritis (RA) medication and identify the associated factors for non-adherence in RA patients.
Methods
Among the KORean Observational study Network for Arthritis 3,523 patients who completed a questionnaire about the adherence to RA medication were analyzed. The patients were divided into two groups: 1) adherent group, patients who skipped medication ≤5 days within the past 2 months; and 2) non-adherent group, patients who skipped ≥6 days of medication. The baseline characteristics were compared, and multivariable regression analysis was performed to identify the associated factors for non-adherence.
Results
The non-adherent group had 339 patients (9.6%). The common causes of non-adherence were forgetfulness (45.8%), absence of RA symptoms (24.7%), and discomfort with RA medication (13.1%). Younger age (odds ratio [OR] 1.02, p<0.01) and higher income (OR 1.70, p<0.01) were associated with an increased risk of non-adherence. Whereas higher functional disability (OR 0.68, p<0.01) and oral corticosteroid use (OR 0.73, p=0.02) were associated with a decreased risk of non-adherence. The associated factors differed according to cause of non-adherence. Having adverse events (OR 2.65, p=0.02) was associated with the risk of non-adherence due to discomfort with RA medication while a higher level of education (OR 2.37, p=0.03) was associated with the risk of non-adherence due to an absence of RA symptoms.
Conclusion
The 9.6% of Korean RA patients were non-adherent to RA medication. The associated factors differed according to the cause of non-adherence. Therefore, an individualized approach will be needed to improve the adherence to RA medication.
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