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Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2-FAM72-|
- Authors
- Nguyen Thi Thanh Ho; Kutzner, Arne; Heese, Klaus
- Issue Date
- Jan-2018
- Publisher
- Walter de Gruyter GmbH
- Keywords
- brain; FAM72; learning; memory; neuron; p17; SRGAP2; synapse
- Citation
- Biological Chemistry, v.399, no.1, pp 55 - 61
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Biological Chemistry
- Volume
- 399
- Number
- 1
- Start Page
- 55
- End Page
- 61
- ISSN
- 1431-6730
1437-4315
- Abstract
- Due to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating the protein 2, family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity. Insight into the specific regulation of the brain-specific neural master gene |-SRGAP2-FAM72-| may essentially contribute to novel therapeutic approaches to restore or improve higher cognitive functions.
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Related Researcher
- Heese, Klaus
- GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING (DEPARTMENT OF BIOMEDICAL SCIENCE)