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Neural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaintsopen access

Authors
Park, SoowonRyu, Seung-HoYoo, YongjoonYang, Jin-JuKwon, HunkiYoun, Jung-HaeLee, Jong MinCho, Seong-JinLee, Jun-Young
Issue Date
Jan-2018
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.8, no.1, pp.1 - 11
Indexed
SCIE
SCOPUS
Journal Title
SCIENTIFIC REPORTS
Volume
8
Number
1
Start Page
1
End Page
11
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150758
DOI
10.1038/s41598-018-19390-2
ISSN
2045-2322
Abstract
Previous studies have indicated that memory training may help older people improve cognition. However, evidence regarding who will benefit from such memory trainings has not been fully discovered yet. Understanding the clinical and neural inter-individual differences for predicting cognitive improvement is important for maximizing the training efficacy of memory-training programs. The purpose of this study was to find the individual characteristics and brain morphological characteristics that predict cognitive improvement after a multi-strategic memory training based on metamemory concept. Among a total of 49 older adults, 39 participated in the memory-training program and 10 did not. All of them underwent brain MRIs at the entry of the training and received the neuropsychological tests twice, before and after the training. Stepwise regression analysis showed that lower years of education predicted cognitive improvement in the training group. In MRI, thinner cortices of precuneus, cuneus and posterior cingulate gyrus and higher white matter anisotropy of the splenium of corpus callosum predicted cognitive improvement in the training group. Old age, lower education level and individual differences in cortical thickness and white matter microstructure of the episodic memory network may predict outcomes following multi-strategic training.
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COLLEGE OF ENGINEERING (서울 바이오메디컬공학전공)
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