Quick sequential organ failure assessment compared to systemic inflammatory response syndrome for predicting sepsis in emergency department
- Authors
- Park, Hyun Kyung; Kim, Won Young; Kim, Myung Chun; Jung, Woong; Ko, Byuk Sung
- Issue Date
- Dec-2017
- Publisher
- W. B. Saunders Co., Ltd.
- Keywords
- Emergency department; Organ failure; qSOFA; Sepsis
- Citation
- Journal of Critical Care, v.42, pp.12 - 17
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Critical Care
- Volume
- 42
- Start Page
- 12
- End Page
- 17
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150922
- DOI
- 10.1016/j.jcrc.2017.06.020
- ISSN
- 0883-9441
- Abstract
- Purpose: It is unclear whether quick sequential (sepsis-related) organ failure assessment (qSOFA) also has prognostic value for organ failure in patients with a suspected infection. The aim of this study was to determine whether qSOFA has prognostic value when compared to systemic inflammatory response syndrome (SIRS) in predicting organ failure in patients with a suspected infection in an emergency department (ED).
Methods: A retrospective observational study was conducted in an ED during a 9-year period. We analyzed the ability of qSOFA compared to SIRS to predict the development of organ failure in patients (defined as an increase in the SOFA score of 2 points or more) using the area under receiver operating characteristic (AUROC) curve.
Results: A total of 1009 patients with suspected infection were finally included in the study. The predictive validity of qSOFA for organ failure was higher than that of SIRS (AUROC=0.814 vs. AUROC=0.662, p=0.02). qSOFA was also superior to SIRS in predicting in-hospital mortality (AUROC=0.733 vs. AUROC=0.599, p=0.04). When the qSOFA score was equal to or > 1, its sensitivity and specificity to predict organ failure was 75% and 82%, respectively.
Conclusions: qSOFA has a superior ability compared to SIRS in predicting the occurrence of organ failure in patients with a suspected infection. However, given the low sensitivity of qSOFA, further confirmatory tests for organ failure are needed. (C) 2017 Elsevier Inc. All rights reserved.
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