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RanBPM: a potential therapeutic target for modulating diverse physiological disorders

Authors
Das, SoumyadipSuresh, BharathiKim, Hyongbum (Henry)Ramakrishna, Suresh
Issue Date
Dec-2017
Publisher
ELSEVIER SCI LTD
Citation
DRUG DISCOVERY TODAY, v.22, no.12, pp.1816 - 1824
Indexed
SCIE
SCOPUS
Journal Title
DRUG DISCOVERY TODAY
Volume
22
Number
12
Start Page
1816
End Page
1824
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151059
DOI
10.1016/j.drudis.2017.08.005
ISSN
1359-6446
Abstract
The Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein involved in a variety of intracellular signaling pathways that control diverse cellular functions. RanBPM interacts with proteins that are linked to various diseases, including Alzheimer's disease (AD), schizophrenia (SCZ), and cancer. In this article, we define the characteristics of the scaffolding protein RanBPM and focus on its interaction partners in diverse physiological disorders, such as neurological diseases, fertility disorders, and cancer.
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Ramakrishna, Suresh
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING (DEPARTMENT OF BIOMEDICAL SCIENCE)
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