RanBPM: a potential therapeutic target for modulating diverse physiological disorders
- Authors
- Das, Soumyadip; Suresh, Bharathi; Kim, Hyongbum (Henry); Ramakrishna, Suresh
- Issue Date
- Dec-2017
- Publisher
- ELSEVIER SCI LTD
- Citation
- DRUG DISCOVERY TODAY, v.22, no.12, pp.1816 - 1824
- Indexed
- SCIE
SCOPUS
- Journal Title
- DRUG DISCOVERY TODAY
- Volume
- 22
- Number
- 12
- Start Page
- 1816
- End Page
- 1824
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151059
- DOI
- 10.1016/j.drudis.2017.08.005
- ISSN
- 1359-6446
- Abstract
- The Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein involved in a variety of intracellular signaling pathways that control diverse cellular functions. RanBPM interacts with proteins that are linked to various diseases, including Alzheimer's disease (AD), schizophrenia (SCZ), and cancer. In this article, we define the characteristics of the scaffolding protein RanBPM and focus on its interaction partners in diverse physiological disorders, such as neurological diseases, fertility disorders, and cancer.
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