NHC-Catalyzed Oxidative Cyclization Reactions of 2-Alkynylbenzaldehydes under Aerobic Conditions: Synthesis of O-Heterocycles
- Authors
- Park, Jong Hyub; Bhilare, Sachin V.; Youn, So Won
- Issue Date
- May-2011
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.13, no.9, pp.2228 - 2231
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC LETTERS
- Volume
- 13
- Number
- 9
- Start Page
- 2228
- End Page
- 2231
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151305
- DOI
- 10.1021/ol200481u
- ISSN
- 1523-7060
- Abstract
- An NHC-catalyzed, regio- and stereoselective oxidative cyclization of o-alkynylbenzaldehydes bearing an unactivated alkyne moiety as an internal electrophile as been developed to afford phthalides and isocoumarins. A single organocatalytic system enabled two sequential C-O bond formations to take place in an atom economical manner via highly efficient dual activation. Molecular oxygen in air could be utilized as a source of an oxygen atom for the oxidation of aldehydes to the corresponding benzoic acids under our newly developed reagent system.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 자연과학대학 > 서울 화학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151305)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.