알츠하이머병 환자에서 정신증적 증상과 연관된 좌측 판개부 및 좌측 외측 후두회의 피질 두께 변화Altered Cortical Thicknesses of Left Pars Opercularis and Left Lateral Occipital Gyrus Can Be Associated with Psychotic Symptoms in Patients with Alzheimer’s Disease
- Other Titles
- Altered Cortical Thicknesses of Left Pars Opercularis and Left Lateral Occipital Gyrus Can Be Associated with Psychotic Symptoms in Patients with Alzheimer’s Disease
- Authors
- 이두형; 김경미; 박선철; 김태형; 최승은; 정태영; 이봉주; 문치웅; 이정구; 김영훈
- Issue Date
- Oct-2017
- Publisher
- 대한노인정신의학회
- Keywords
- Alzheimer’s disease; Left lateral occipital gyrus; Left pars opercularis; Psychotic symptoms
- Citation
- 노인정신의학, v.21, no.2, pp.67 - 74
- Indexed
- KCI
- Journal Title
- 노인정신의학
- Volume
- 21
- Number
- 2
- Start Page
- 67
- End Page
- 74
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151450
- ISSN
- 1226-6329
- Abstract
- Objective:The aims of this study was to present an association between the presence of psychotic symptoms and cortical thicknesses/ subcortical volumes in patients with Alzheimer’s disease (AD).
Methods:Fourteen AD patients with psychotic symptoms and 41 without psychotic symptoms underwent 3T MRI scanning. After adjusting the effects of confounding variables, the cortical thicknesses were compared between the AD patients with and without psychotic symptoms in multiple regions, across the continuous cortical surface. In addition, the subcortical volumes were compared with a structure-by-structure manner.
Results:AD patients with psychotic symptoms were characterized by significant smaller cortical thickness of left pars opercularis (F=4.67, p=0.02) and left lateral occipital gyrus (F=6.05, p=0.04) rather than those without psychotic symptoms, after adjusting the effects of age and scores on the Stroop test, non-psychotic items of Neuropsychiatry Inventory and Clinical Dementia Rating, triglyceride level and total intracranial volume. However, there were no significant differences in the subcortical volume between the two groups.
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