Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphomaopen access
- Authors
- Song, Moo-Kon; Chung, Joo-Seop; Yhim, Ho-Young; Lim, Sung-Nam; Kim, Seong-Jang; Han, Yeon-Hee; Shim, Hye-Kyung; Jung, Sung-Hoon; Lee, Je-Jung; Yang, Deok-Hwan
- Issue Date
- Oct-2017
- Publisher
- IMPACT JOURNALS LLC
- Keywords
- extranodal natural killer/T-cell lymphoma; tumor necrosis; complete resection; prognosis
- Citation
- ONCOTARGET, v.8, no.45, pp.79337 - 79346
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOTARGET
- Volume
- 8
- Number
- 45
- Start Page
- 79337
- End Page
- 79346
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151521
- DOI
- 10.18632/oncotarget.18107
- ISSN
- 1949-2553
- Abstract
- Tumor necrosis (TN) is associated with worse prognosis in several solid cancers. Whether TN predicts poor outcome in natural killer cell / T cell lymphoma (NKTCL) is unclear. We investigated the clinical impact of TN on survival and other novel prognostic parameters in upper aero-digestive tract (UAT) NKTCL of 100 patients with limited stage. TN was significantly associated with poor performance status (p = 0.049), high Korean Prognostic Index score (p = 0.024), high C-reactive protein/albumin ratio (p = 0.003), higher maximum standard uptake value on positron emission tomography/computed tomography (PET/CT) (p = 0.008) and higher metabolic tumor volume (MTV) on PET/CT (p < 0.001). In univariate and multivariate analyses, progression-free survival and overall survival were independently associated with High MTV status (p = 0.001, p = 0.032), TN (p = 0.018, p = 0.009), local tumor invasiveness (p = 0.007, p = 0.035), complete resection (p = 0.020, p = 0.028) and regional lymph node involvement (p < 0.001, p < 0.001). TN and complete resection are concluded to be novel independent prognostic factors in patients with UAT NKTCL.
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