Genome editing: a robust technology for human stem cells
DC Field | Value | Language |
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dc.contributor.author | Chandrasekaran, Arun, Pandian | - |
dc.contributor.author | Song, Minjung | - |
dc.contributor.author | Ramakrishna, Suresh | - |
dc.date.accessioned | 2022-07-13T11:35:17Z | - |
dc.date.available | 2022-07-13T11:35:17Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/151678 | - |
dc.description.abstract | Human pluripotent stem cells comprise induced pluripotent and embryonic stem cells, which have tremendous potential for biological and therapeutic applications. The development of efficient technologies for the targeted genome alteration of stem cells in disease models is a prerequisite for utilizing stem cells to their full potential. Genome editing of stem cells is possible with the help of synthetic nucleases that facilitate site-specific modification of a gene of interest. Recent advances in genome editing techniques have improved the efficiency and speed of the development of stem cells for human disease models. Zinc finger nucleases, transcription activator- like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system are powerful tools for editing DNA at specific loci. Here, we discuss recent technological advances in genome editing with site-specific nucleases in human stem cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.title | Genome editing: a robust technology for human stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ramakrishna, Suresh | - |
dc.identifier.doi | 10.1007/s00018-017-2522-0 | - |
dc.identifier.scopusid | 2-s2.0-85017476025 | - |
dc.identifier.wosid | 000406938400006 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR LIFE SCIENCES, v.74, no.18, pp.3335 - 3346 | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.title | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.volume | 74 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 3335 | - |
dc.citation.endPage | 3346 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ZINC-FINGER NUCLEASES | - |
dc.subject.keywordPlus | DOUBLE-STRAND BREAKS | - |
dc.subject.keywordPlus | HUMAN HEMATOPOIETIC STEM | - |
dc.subject.keywordPlus | TAL EFFECTOR NUCLEASES | - |
dc.subject.keywordPlus | DNA-BINDING SPECIFICITY | - |
dc.subject.keywordPlus | GENE CORRECTION | - |
dc.subject.keywordPlus | HOMOLOGOUS RECOMBINATION | - |
dc.subject.keywordPlus | CRISPR-CAS9 NUCLEASES | - |
dc.subject.keywordPlus | LENTIVIRAL VECTOR | - |
dc.subject.keywordPlus | HUMAN BLASTOCYSTS | - |
dc.subject.keywordAuthor | Induced pluripotent stem cells | - |
dc.subject.keywordAuthor | Embryonic stem cells | - |
dc.subject.keywordAuthor | Zinc finger nucleases | - |
dc.subject.keywordAuthor | Transcription activator-like effector nucleases | - |
dc.subject.keywordAuthor | Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00018-017-2522-0 | - |
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