Distinct clinical characteristics of anti-Ro/SSA-negative primary Sjogren's syndrome: data from a nationwide cohort for Sjogren's syndrome in KoreaDistinct clinical characteristics of anti-Ro/SSA-negative primary Sjögren's syndrome: Data from a nationwide cohort for Sjögren's syndrome in Kore
- Other Titles
- Distinct clinical characteristics of anti-Ro/SSA-negative primary Sjögren's syndrome: Data from a nationwide cohort for Sjögren's syndrome in Kore
- Authors
- Park, Y.; Lee, J.; Koh, J. H.; Sung, Y. -K.; Lee, S. -S.; Choe, J. Y.; Shim, S. -C.; Kim, J. -M.; Kwon, S. R.; Kim, H. -O.; Chung, S. -H.; Park, S. -H.; Kwok, S. -K.
- Issue Date
- 2019
- Publisher
- CLINICAL & EXPER RHEUMATOLOGY
- Keywords
- Sjogren' s syndrome; Ro antibody; minor salivary glands
- Citation
- CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v.37, no.3, pp.S107 - S113
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
- Volume
- 37
- Number
- 3
- Start Page
- S107
- End Page
- S113
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15178
- ISSN
- 0392-856X
- Abstract
- Objectives: To investigate clinical characteristics of patients with primary Sjogren's syndrome (SS) who were negative for anti-Ro/SSA antibody but positive for minor salivary gland biopsy (MSGB) compared to patients who presented positivity for anti-Ro/SSA antibody.
Methods: The data of 355 patients from the Korean Initiative of primary Sjogren's Syndrome (KISS), a nationwide prospective cohort for primary SS in Korea, were analysed. All patients fulfilled the 2016 American College of Rheumatology/European League Against Rheumatism (EULAR) classification criteria. Of these patients, 326 were positive for anti-Ro/SSA antibody and 29 were antibody-negative, although they had positive findings in MSGB. Various clinical features including all kinds of tests for evaluating secretory function, disease-related clinical indices and serological values available in the cohort were compared between the two groups.
Results: The anti-Ro/SSA-negative group showed less rheumatoid factor positivity (p<0.001), leucopenia (p=0.003), hyper-gammaglobulinaemia (p<0.001), lower serum ß₂-microglobulin level (p=0.034), more anti-centromere antibody positivity (p<0.001), higher score in dryness domain of EULAR SS patient-reported index (p=0.048) and more positivity for peripheral nervous system domain in EULAR SS disease activity index and loss of teeth in SS disease damage index (p=0.021 and 0.041, respectively) than patients who were positive for anti-Ro/SSA antibody.
Conclusions: Primary SS patients who are negative for anti-Ro/SSA antibody have different clinical characteristics compared to patients who are positive for such antibody in Korea. Therefore, clinicians should consider MSGB in patients with suspicious symptoms who are anti-Ro/SSA-negative.
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