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Palladium-Catalyzed Regioselective Synthesis of 3-Arylindoles from N-Ts-Anilines and Styrenes

Authors
Youn, So WonKo, Tae YunJang, Young Ho
Issue Date
Jun-2017
Publisher
WILEY-V C H VERLAG GMBH
Keywords
C-H activation; homogeneous catalysis; indoles; palladium; regioselectivity
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.56, no.23, pp.6636 - 6640
Indexed
SCIE
SCOPUS
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume
56
Number
23
Start Page
6636
End Page
6640
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152244
DOI
10.1002/anie.201702205
ISSN
1433-7851
Abstract
A Pd-catalyzed intermolecular oxidative annulation between N-Ts-anilines and styrenes was developed. This method offers a straightforward and robust approach to a wide range of 3-arylindoles using readily available starting materials with good functional-group tolerance and high regioselectivity and efficiency. Further elaboration of the products obtained from this process provided access to highly functionalized and structurally diverse indoles, for example, 3-(indol-3-yl)carbazoles, 1,9-dihydropyrrolo-[2,3-b]carbazoles, and 3'-aryl-3,5'-biindoles.
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