Deubiquitylation of deubiquitylasesopen access
- Authors
- Haq, Saba; Ramakrishna, Suresh
- Issue Date
- Jun-2017
- Publisher
- ROYAL SOC
- Keywords
- auto-regulation; deubiquitylating DUBs; proteasome degradation; self-deubiquitylation; ubiquitylation
- Citation
- OPEN BIOLOGY, v.7, no.6, pp.1 - 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- OPEN BIOLOGY
- Volume
- 7
- Number
- 6
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152265
- DOI
- 10.1098/rsob.170016
- ISSN
- 2046-2441
- Abstract
- Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. In contrast to the plethora of research being conducted on the ability of DUBs to counter the degradation of cellular proteins or auto-ubiquitylated E3 ligases, very little is known about the mechanisms of DUB regulation. In this review paper, we summarize a novel possible mechanism of DUB deubiquitylation by other DUBs. The available data suggest the need for further experiments to validate and characterize this notion of 'Dubbing DUBs'. The current studies indicate that the idea of deubiquitylation of DUBs by other DUBs is still in its infancy. Nevertheless, future research holds the promise of validation of this concept.
- Files in This Item
-
- Appears in
Collections - 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152265)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.