Comparative characteristics of quantitative indexes for F-18-FDG uptake and metabolic volume in sequentially obtained PET/MRI and PET/CT
- Authors
- Lee, Soo Jin; Paeng, Jin Chul; Goo, Jin Mo; Lee, Jeong Min; Cheon, Gi Jeong; Lee, Dong Soo; Chung, June-Key; Kang, Keon Wook
- Issue Date
- Apr-2017
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- cancer; correlation study; MRI; PET; tumor volume
- Citation
- Nuclear Medicine Communications, v.38, no.4, pp.333 - 339
- Indexed
- SCIE
SCOPUS
- Journal Title
- Nuclear Medicine Communications
- Volume
- 38
- Number
- 4
- Start Page
- 333
- End Page
- 339
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152656
- DOI
- 10.1097/MNM.0000000000000655
- ISSN
- 0143-3636
- Abstract
- Purpose
The purpose of this study was to compare quantitative indexes for fluorine-18 fluorodeoxyglucose uptake and metabolic volume between PET/MRI and PET/CT.
Patients and methods
Sixty-six patients with solid tumors (32 with lung cancer and 34 with pancreatic cancer) who underwent sequential fluorine-18 fluorodeoxyglucose PET/MRI and PET/CT were retrospectively enrolled. On PET images, maximum and peak standardized uptake values (SUVmax and SUVpeak, respectively), and maximum tumor-to-liver ratio (TLRmax) were measured. Metabolic tumor volume (MTV) and total-lesion glycolysis (TLG) with margin thresholds of 50% SUVmax and SUV 2.5 (MTV50%, MTV2.5; TLG50%, TLG2.5, respectively) were compared between PET/MRI and PET/CT, with patients classified into two groups using imaging protocol (the PET/MRI-first and PET/CT-first groups).
Results
There were significant correlations of all tested indexes between PET/MRI and PET/CT (r=0.867–0.987, P<0.001). SUVmax and SUVpeak were lower on PET/MRI regardless of imaging protocol (P<0.001 in the PET/MRI-first group). In contrast, TLRmax exhibited reverse results between the PET/MRI-first and PET/CT-first groups. MTV50% and TLG values varied between PET/MRI and PET/CT, as well as between the PET/MRI-first and PET/CT-first groups. However, MTV2.5 was relatively robust against imaging protocol and modality.
Conclusion
There are significant correlations of the quantitative indexes between PET/MRI and PET/CT. However, uptake indexes of SUVmax and SUVpeak are lower on PET/MRI than on PET/CT, and volumetric indexes of MTV50% and TLG values also exhibited significant differences. It may be suggested that TLRmax and MTV2.5 are relatively more appropriate indexes than others when PET/MRI and PET/CT are used interchangeably.
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