Synergistic attenuation of ovariectomy-induced bone loss by combined use of fish oil and 17β-oestradiol
DC Field | Value | Language |
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dc.contributor.author | Jin, Youri | - |
dc.contributor.author | Lee, Myoungsook | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2022-07-14T17:02:04Z | - |
dc.date.available | 2022-07-14T17:02:04Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152966 | - |
dc.description.abstract | Oestrogen and n-3 PUFA, especially EPA and DHA, have been reported to have beneficial effects on bone loss. Thus, the purpose of the present study was to investigate the synergistic bone-protective mechanism of combined treatments of EPA+DHA supplementation and oestrogen injection in ovariectomised rats. Rats were fed a modified American Institute of Nutrition-93G diet with 0 %, 1 % or 2 % n-3 PUFA (EPA+DHA) relative to the total energy intake for 12 weeks. Rats were surgically ovariectomised at week 8, and after a 1-week recovery period rats were injected with either 17β-oestradiol-3-benzoate (E₂) or maize oil for the last 3 weeks. Combined use of n-3 PUFA and E₂ synergistically increased femoral cortical bone volume, bone mineral content and the bone expression of runt-related transcription factor 2 (RUNX2), but decreased the bone expression of IL-1β. Both n-3 PUFA and E₂ decreased the bone expressions of IL-7, TNF-α and PPAR-γ, and increased the bone expression of oestrogen receptor-α. n-3 PUFA in the presence of E₂ and E₂ alone significantly decreased the bone expressions of IL-1β and IL-6 and increased the bone expression of RUNX2. E₂ significantly decreased the serum levels of bone turnover markers and the bone expression of receptor activator of NF-κB ligand, but decreased the bone expression of osteoprotegerin. The combined use of n-3 PUFA and E₂ exerted synergistic bone-protective efficacy through up-regulation of RUNX2, an essential transcription factor for bone formation, as well as the suppression of bone-resorbing cytokine IL-1β. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.title | Synergistic attenuation of ovariectomy-induced bone loss by combined use of fish oil and 17β-oestradiol | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.1017/S0007114517000344 | - |
dc.identifier.scopusid | 2-s2.0-85015211746 | - |
dc.identifier.wosid | 000399336800001 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF NUTRITION, v.117, no.4, pp.479 - 489 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.title | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.volume | 117 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 489 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | DOSE ESTROGEN THERAPY | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | N-3 | - |
dc.subject.keywordPlus | OSTEOPROTEGERIN | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordAuthor | 17β-Oestradiol-3-benzoate | - |
dc.subject.keywordAuthor | n-3 PUFA | - |
dc.subject.keywordAuthor | Bone loss | - |
dc.subject.keywordAuthor | Runt-related transcription factor 2 | - |
dc.subject.keywordAuthor | IL-1β | - |
dc.identifier.url | https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/synergistic-attenuation-of-ovariectomyinduced-bone-loss-by-combined-use-of-fish-oil-and-17oestradiol/FAA4B8848B9C5D448F354E2954C26705 | - |
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