Education level is a strong prognosticator in the subgroup aged more than 50 years regardless of the molecular subtype of breast cancer: A study based on the Nationwide Korean breast cancer registry databaseopen access
- Authors
- Hwang, Ki-Tae; Noh, Woochul; Cho, Se-Heon; Yu, Jonghan; Park, Min Ho; Jeong, Joon; Lee, Hyouk Jin; Kim, Jongjin; Kim, Young A; Oh, Sohee; Ahn, Sei Hyun; Noh, Dong-Young; Nam, Seok Jin; Kim, Sung Yong; Lee, Eun Sook; Park, Byeong-Woo; Noh, W.C.; Yoon, Jung Han; Lee, Soo Jung; Lee, Eun Kyu; Han, Sehwan; Park, Ho Yong; Paik, Nam-Sun; Bae, Young Tae; Park, Heung kyu; Ko, Seung Sang; Song, Byung Joo; Suh, Young Jin; Jung, Sung Hoo; Cho, Se Heon; Kim, Sei Joong; Oh, Se Jeong; Ko, Byung Kyun; Kim, Ku Sang; Park, Chanheun; Baek, Jong-Min; Chang, Il-Sung; Bae, Jeoung Won; Kim, Jeong- Soo; Kang, Sun Hee; Gwak, Geumhee; Lee, Jee Hyun; Kim, Tae Hyun; Chang, Myungchul; Lee, Jung Sun; Song, Jeong-Yoon; Park, Hai Lin; Min, Sun Young; Yang, Jung-Hyun; Park, Sung Hwan; Park, Woo-Chan; Kim, Lee Su; Ryu, Dong Won; Kim, Kweon Cheon; Chung, Min Sung; Park, Hee Boong; Lim, Cheol Wan; Choi, Un Jong; Kwak, Beom Seok; Park, Young Sam; Shin, Hyuk Jai; Choi, Young Jin; Kim, Doyil; Han, Airi; Koh, Jong Hyun; Choi, Sangyong; Yoon, Daesung; Choi, Soo Youn; Chul, Shin Hee; Kim, Jae Il; Choi, Jae Hyuck; Ryu, Jin Woo; Ko, Chang Dae; Lee, Il Kyun; Lee, Dong Seok; Choi, Seunghye; Min, Youn Ki; Jeon, Young San; Park, Eun-Hwa; Korean Breast Cancer Society
- Issue Date
- Feb-2017
- Publisher
- Korean Cancer Association
- Keywords
- Breast neoplasms; Education; Educational status; Prognosis; Survival analysis
- Citation
- Cancer Research and Treatment, v.49, no.4, pp.1114 - 1126
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Cancer Research and Treatment
- Volume
- 49
- Number
- 4
- Start Page
- 1114
- End Page
- 1126
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152990
- DOI
- 10.4143/crt.2016.528
- ISSN
- 1598-2998
- Abstract
- Purpose
This study investigated the role of the education level (EL) as a prognostic factor for breast cancer and analyzed the relationship between the EL and various confounding factors.
Materials and Methods
The data for 64,129 primary breast cancer patients from the Korean Breast Cancer Registry were analyzed. The EL was classified into two groups according to the education period; the high EL group (≥ 12 years) and low EL group (< 12 years). Survival analyses were performed with respect to the overall survival between the two groups.
Results
A high EL conferred a superior prognosis compared to a low EL in the subgroup aged > 50 years (hazard ratio, 0.626; 95% confidence interval [CI], 0.577 to 0.678) but not in the subgroup aged ≤ 50 years (hazard ratio, 0.941; 95% CI, 0.865 to 1.024). The EL was a significant independent factor in the subgroup aged > 50 years according to multivariate analyses. The high EL group showed more favorable clinicopathologic features and a higher proportion of patients in this group received lumpectomy, radiation therapy, and endocrine therapy. In the high EL group, a higher proportion of patients received chemotherapy in the subgroups with unfavorable clinicopathologic features. The EL was a significant prognosticator across all molecular subtypes of breast cancer.
Conclusion
The EL is a strong independent prognostic factor for breast cancer in the subgroup aged > 50 years regardless of the molecular subtype, but not in the subgroup aged ≤ 50 years. Favorable clinicopathologic features and active treatments can explain the main causality of the superior prognosis in the high EL group.
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