Effect of Intravenous Infusion of G-CSF-Mobilized Peripheral Blood Mononuclear Cells on Upper Extremity Function in Cerebral Palsy Childrenopen access
- Authors
- Park, Kyeong Il; Lee, Young-Ho; Rah, Wee-Jin; Jo, Seung Hwi; Park, Si-Bog; Han, Seung Hoon; Koh, Hani; Suh, Jin Young; Um, Jang Soo; Choi, Eun Hye; Park, Un Jin; Kim, Mi Jung
- Issue Date
- Feb-2017
- Publisher
- KOREAN ACAD REHABILITATION MEDICINE
- Keywords
- Cerebral palsy; Peripheral blood stem cell transplantation; Granulocyte colony-stimulating factor; Upper extremity
- Citation
- ANNALS OF REHABILITATION MEDICINE-ARM, v.41, no.1, pp.113 - 120
- Indexed
- SCOPUS
KCI
- Journal Title
- ANNALS OF REHABILITATION MEDICINE-ARM
- Volume
- 41
- Number
- 1
- Start Page
- 113
- End Page
- 120
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152997
- DOI
- 10.5535/arm.2017.41.1.113
- ISSN
- 2234-0645
- Abstract
- Objective To investigate the effect of intravenous infusion of peripheral blood mononuclear cells (mPBMC) mobilized by granulocyte-colony stimulating factor (G-CSF) on upper extremity function in children with cerebral palsy (CP). Methods Fifty-seven children with CP were enrolled. Ten patients were excluded due to follow-up loss. In total, 47 patients (30 males and 17 females) were analyzed. All patients' parents provided signed consent before the start of the study. After administration of G-CSF for 5 days, mPBMC was collected and cryopreserved. Patients were randomized into two groups 1 month later. Twenty-two patients were administered mPBMC and 25 patients received normal saline as placebo. Six months later, the two groups were switched, and administered mPBMC and placebo, respectively. Quality of Upper Extremity Skills Test (QUEST) and the Manual Ability Classification System (MACS) were used to evaluate upper motor function. Results All subdomain and total scores of QUEST were significantly improved after mPBMC and placebo infusion, without significant differences between mPBMC and placebo groups. A month after G-CSF, all subdomain and total scores of QUEST were improved. The level of MACS remained unchanged in both mPBMC and placebo groups. Conclusion In this study, intravenously infused mPBMC showed no significant effect on upper extremity function in children with CP, as compared to placebo. The effect of mPBMC was likely masked by the effect of G-CSF, which was used in both groups and/or G-CSF itself might have other neurotrophic potentials in children with CP.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 재활의학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 소아청소년과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/152997)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.