Tumor necrosis could reflect advanced disease status in patients with diffuse large B cell lymphoma treated with R-CHOP therapy
- Authors
- Song, Moo-Kon; Chung, Joo-Seop; Shin, Dong-Yeop; Lim, Sung-Nam; Lee, Gyeong-won; Choi, Jae-Cheol; Park, Won-Young; Oh, So-Yeon
- Issue Date
- Jan-2017
- Publisher
- SPRINGER
- Keywords
- Tumor necrosis; Diffuse large B cell lymphoma; Ann Arbor stage; Survival
- Citation
- ANNALS OF HEMATOLOGY, v.96, no.1, pp.17 - 23
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF HEMATOLOGY
- Volume
- 96
- Number
- 1
- Start Page
- 17
- End Page
- 23
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153066
- DOI
- 10.1007/s00277-016-2822-8
- ISSN
- 0939-5555
- Abstract
- Tumor necrosis (TN) can lower responsiveness to chemotherapy and confer basic resistance to anti-cancer therapy. We investigated the association of TN with poor clinical features and outcome in diffuse large B cell lymphoma (DLBCL). We examined the presence or absence of TN in 476 DLBCL patients of who received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy. Eighty-nine (18.7 %) patients had TN at diagnosis. Patients with TN had a progression-free survival (PFS) and overall survival (OS) of 39.3 and 46.7 %, whereas patients without TN had a PFS and OS of 73.4 and 82.6 %. Adverse clinical factors of poor Eastern Cooperative Oncology Group performance status ≥ grade 2 (p = 0.005), elevated lactate dehydrogenase ratio >1 (p < 0.001), advanced Ann Arbor stage (p = 0.002), and bulky disease (p = 0.026) were more prevalent in the TN group than the non-TN group. Cox regression model analysis revealed TN as an independent prognostic factor for PFS and OS in DLBCL (PFS, hazard ratio [HR] = 1.967, 95 % confidence interval [CI] = 1.399–2.765, p < 0.001; OS, HR = 2.445, 95 % CI = 1.689–3.640, p < 0.001). The results indicate that TN could reflect adverse clinical features and worse prognosis in DLBCL patients receiving R-CHOP therapy.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 교육협력지원교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153066)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.