Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes
- Authors
- Park, Hee Kyung; Park, Kee Hyung; Yoon, Bora; Lee, Jae -Hong; Choi, Seong Hye; Joung, Jee H.; Yoon, Soo Jin; Kim, Byeong C.; Kim, Seung Hyun; Kim, Eun-Joo; Na, Duk L.; Park, Kyung Won
- Issue Date
- Jan-2017
- Publisher
- ELSEVIER
- Keywords
- Parkinsonism; Frontotemporal dementia; Primary progressive aphasia; Motor neuron disease
- Citation
- JOURNAL OF THE NEUROLOGICAL SCIENCES, v.372, pp.51 - 56
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE NEUROLOGICAL SCIENCES
- Volume
- 372
- Start Page
- 51
- End Page
- 56
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153115
- DOI
- 10.1016/j.jns.2016.11.033
- ISSN
- 0022-510X
- Abstract
- Background
We investigated the prevalence of parkinsonism in frontotemporal dementia (FTD) subtypes and the cognitive and behavioral differences between FTD with and without parkinsonism in a well-structured, prospective cohort.
Methods
One hundred and ninety-one FTD patients were enrolled and all patients underwent comprehensive neurological evaluations, neuropsychological tests, and the Unified Parkinson's Disease Rating Scale.
Results
The prevalence of parkinsonism was 38.7% (74 patients), and included 33 (46.5%) behavioral variant FTD (bvFTD), 16 (24.2%) semantic dementia (SD), 19 (45.2%) progressive nonfluent aphasia (PNFA), and 6 (50%) FTD associated with motor neuron disease (FTD-MND). SD patients with parkinsonism had higher CDR sum of boxes scores (9.7 ± 4.5 vs 6.2 ± 4.5, p = 0.024), frontal behavioral inventory total score (33.7 ± 20.5 vs 24.3 ± 14.5, p = 0.045), and executive function score of frontal executive dysfunction, disinhibition, and apathy (28.9 ± 13.7 vs 19.2 ± 12.9, p = 0.021) than those without parkinsonism. Seoul Instrumental Activities of Daily Living score (bvFTD: 23.5 ± 11.7 vs 17.3 ± 11.3, p = 0.031, SD: 23.1 ± 11.1 vs 11.3 ± 9.3, p = 0.005) was higher for bvFTD and SD with parkinsonism than for those without parkinsonism.
Conclusions
Parkinsonism is found to be more common in patients with bvFTD, PNFA, and FTD-MND patients than those with SD. Behavioral disturbances were more prominent in SD with parkinsonism than without. Additional studies are needed to determine the pathomechanism and optimal treatment of parkinsonism in different FTD subtypes.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 신경과학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.