How many different symptom combinations fulfil the diagnostic criteria for major depressive disorder? Results from the CRESCEND study
- Authors
- Park, Seon-Cheol; Kim, Jae-Min; Jun, Tae-Youn; Lee, Min-Soo; Kim, Jung-Bum; Yim, Hyeon-Woo; Park, Yong Chon
- Issue Date
- 2017
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Major depressive disorder; depressive symptom combinations; polythetic definition; diagnostic heterogeneity; family resemblances
- Citation
- NORDIC JOURNAL OF PSYCHIATRY, v.71, no.3, pp.217 - 222
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- NORDIC JOURNAL OF PSYCHIATRY
- Volume
- 71
- Number
- 3
- Start Page
- 217
- End Page
- 222
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153271
- DOI
- 10.1080/08039488.2016.1265584
- ISSN
- 0803-9488
- Abstract
- Background: The polythetic nature of major depressive disorder (MDD) in DSM- IV and DSM-5 inevitably leads to diagnostic heterogeneity.Aims: This study aimed to identify the number of depressive symptom combinations actually fulfilling the DSM-IV diagnostic criteria that can be found in Korean MDD patients and the relative frequencies of each combination.Methods: Using the data from the Clinical Research Center for Depression (CRESCEND) study in South Korea, we enrolled 853 MDD patients diagnosed using DSM-IV and scored as 8 or more on the Hamilton Depression Rating Scale (HAMD). Descriptive statistical analyses were performed to reveal the degree of diagnostic heterogeneity of the MDD.Results: This study identified 119 different depressive symptom combinations. The most common combination consisted of all nine depressive symptom profiles, and nine different combinations were each present in more than 3% of the patients.Conclusion: The findings support the criticism that the diagnosis of MDD is not based on a single mental process, but on a set of family resemblances'.
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