Programmed death-ligand 1 expression in gastric adenocarcinoma is a poor prognostic factor in a high CD8+ tumor infiltrating lymphocytes groupopen access
- Authors
- Chang, Hyeyoon; Jung, Woon Yong; Kang, Youngran; Lee, Hyunjoo; Kim, Aeree; Kim, Han Kyeom; Shin, Bong Kyung; Kim, Baek-Hui
- Issue Date
- Dec-2016
- Publisher
- IMPACT JOURNALS LLC
- Keywords
- gastric adenocarcinoma; PD-1; PD-L1; CTLA-4; prognosis
- Citation
- ONCOTARGET, v.7, no.49, pp.80426 - 80434
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOTARGET
- Volume
- 7
- Number
- 49
- Start Page
- 80426
- End Page
- 80434
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153313
- DOI
- 10.18632/oncotarget.12603
- ISSN
- 1949-2553
- Abstract
- Gastric adenocarcinoma is one of the most common causes of cancer-related death. In this study, we conducted immunohistochemical studies for PD-L1, PD-1, CTLA-4, and CD8 using tissue microarrays from 464 gastric cancer samples and evaluated the correlations between their expression, clinicopathologic factors, and five-year overall survival. PD-L1 and PD-1 expression was significantly correlated with several adverse prognostic pathologic factors, including higher T-stage, diffuse Lauren histologic type, and lymphatic invasion. Conversely, CTLA-4 expression was correlated with factors of favorable clinical outcomes. A complete case analysis revealed that high PD-L1 and PD-1 expression had an adverse effect on five-year overall survival in univariate analyses. Subgroup analyses wherein patients were divided into two groups according to CD8+ tumor infiltrating lymphocyte levels (high and low) showed that high PD-L1 expression was a significant adverse prognostic factor only in the high CD8+ tumor-infiltrating lymphocytes group. Further research and clinical trials are needed to determine the clinical usefulness of these findings.
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