Loss of APAF-1 expression is associated with early recurrence in stage I, II, and III colorectal cancer
DC Field | Value | Language |
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dc.contributor.author | Ahn, Byung kyu | - |
dc.contributor.author | Kim, Sung Hoo | - |
dc.contributor.author | Paik, Seung Sam | - |
dc.contributor.author | Lee, Kang Hong | - |
dc.date.accessioned | 2022-07-14T23:59:37Z | - |
dc.date.available | 2022-07-14T23:59:37Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1435-2443 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153440 | - |
dc.description.abstract | Purpose Apoptotic protease activating factor-1 (APAF-1) is a key regulator in the mitochondrial apoptotic pathway and an important diagnostic and therapeutic biomarker. Loss of APAF-1 expression has been observed in various tumors including colorectal cancer. The aim of our study was to evaluate the relationship between loss of APAF-1 expression and early recurrence of stage I–III colorectal cancer. Methods We investigated 165 out of 492 patients who had undergone curative resection for colorectal cancer between 1991 and 2001. Sixty-one patients (37.0 %) had early recurrence within 1 year after surgery. Tissue microarrays were used for immunohistochemical detection of APAF-1. Results The mean age of patients with recurrence was 58 years (range, 24–85); 88 (53.3 %, 88/165) were male. APAF-1 was expressed in 32 (19.4 %, 32/165) cases and was not expressed in 133 (80.6 %, 133/165). In univariate analysis, early recurrence significantly correlated with loss of APAF-1 expression (p = 0.017), tumor stage (p = 0.005), N category (p = 0.001), and lymphatic invasion (p = 0.008). In a logistic regression model, loss of APAF-1 expression (p = 0.015, 95 % CI = 1.280–10.063) and N category (p = 0.001, 95 % CI = 0.004–0.739) proved to be independent risk factors associated with early recurrence. In patients with lymph node metastasis, early recurrence was more frequent in the APAF-1-negative group than in the APAF-1-positive group (46.2 % (54/117) vs. 22.2 % (6/27), p = 0.023). Conclusions Loss of APAF-1 expression is associated with early recurrence in stage I–III colorectal cancer, suggesting that APAF-1 may have clinical value as a predictive marker of early recurrence. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Loss of APAF-1 expression is associated with early recurrence in stage I, II, and III colorectal cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Byung kyu | - |
dc.contributor.affiliatedAuthor | Paik, Seung Sam | - |
dc.contributor.affiliatedAuthor | Lee, Kang Hong | - |
dc.identifier.doi | 10.1007/s00423-016-1483-3 | - |
dc.identifier.scopusid | 2-s2.0-84982852173 | - |
dc.identifier.wosid | 000390032200012 | - |
dc.identifier.bibliographicCitation | LANGENBECKS ARCHIVES OF SURGERY, v.401, no.8, pp.1203 - 1210 | - |
dc.relation.isPartOf | LANGENBECKS ARCHIVES OF SURGERY | - |
dc.citation.title | LANGENBECKS ARCHIVES OF SURGERY | - |
dc.citation.volume | 401 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1203 | - |
dc.citation.endPage | 1210 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | CURATIVE RESECTION | - |
dc.subject.keywordPlus | MELANOMA PROGRESSION | - |
dc.subject.keywordPlus | CUTANEOUS MELANOMA | - |
dc.subject.keywordPlus | TUMOR PROGRESSION | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CHEMORESISTANCE | - |
dc.subject.keywordPlus | 5-FLUOROURACIL | - |
dc.subject.keywordAuthor | APAF-1 | - |
dc.subject.keywordAuthor | Early | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordAuthor | Colorectal cancer | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00423-016-1483-3 | - |
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