Loss of APAF-1 expression is associated with early recurrence in stage I, II, and III colorectal cancer
- Authors
- Ahn, Byung kyu; Kim, Sung Hoo; Paik, Seung Sam; Lee, Kang Hong
- Issue Date
- Dec-2016
- Publisher
- SPRINGER
- Keywords
- APAF-1; Early; Recurrence; Colorectal cancer
- Citation
- LANGENBECKS ARCHIVES OF SURGERY, v.401, no.8, pp.1203 - 1210
- Indexed
- SCIE
SCOPUS
- Journal Title
- LANGENBECKS ARCHIVES OF SURGERY
- Volume
- 401
- Number
- 8
- Start Page
- 1203
- End Page
- 1210
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153440
- DOI
- 10.1007/s00423-016-1483-3
- ISSN
- 1435-2443
- Abstract
- Purpose
Apoptotic protease activating factor-1 (APAF-1) is a key regulator in the mitochondrial apoptotic pathway and an important diagnostic and therapeutic biomarker. Loss of APAF-1 expression has been observed in various tumors including colorectal cancer. The aim of our study was to evaluate the relationship between loss of APAF-1 expression and early recurrence of stage I–III colorectal cancer.
Methods
We investigated 165 out of 492 patients who had undergone curative resection for colorectal cancer between 1991 and 2001. Sixty-one patients (37.0 %) had early recurrence within 1 year after surgery. Tissue microarrays were used for immunohistochemical detection of APAF-1.
Results
The mean age of patients with recurrence was 58 years (range, 24–85); 88 (53.3 %, 88/165) were male. APAF-1 was expressed in 32 (19.4 %, 32/165) cases and was not expressed in 133 (80.6 %, 133/165). In univariate analysis, early recurrence significantly correlated with loss of APAF-1 expression (p = 0.017), tumor stage (p = 0.005), N category (p = 0.001), and lymphatic invasion (p = 0.008). In a logistic regression model, loss of APAF-1 expression (p = 0.015, 95 % CI = 1.280–10.063) and N category (p = 0.001, 95 % CI = 0.004–0.739) proved to be independent risk factors associated with early recurrence. In patients with lymph node metastasis, early recurrence was more frequent in the APAF-1-negative group than in the APAF-1-positive group (46.2 % (54/117) vs. 22.2 % (6/27), p = 0.023).
Conclusions
Loss of APAF-1 expression is associated with early recurrence in stage I–III colorectal cancer, suggesting that APAF-1 may have clinical value as a predictive marker of early recurrence.
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