Interleukin 17-expressing Innate Synovial Cells Drive K/BxN Serum-induced Arthritis
- Authors
- Cho, Wang Shik; Jang, Eunkyeong; Kim, Ho-Youn; Youn, Jeehee
- Issue Date
- Dec-2016
- Publisher
- 대한면역학회
- Keywords
- IL-17; Synovial cells; Arthritis; Immune complex
- Citation
- Immune Network, v.16, no.6, pp.366 - 372
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Immune Network
- Volume
- 16
- Number
- 6
- Start Page
- 366
- End Page
- 372
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153459
- DOI
- 10.4110/in.2016.16.6.366
- ISSN
- 1598-2629
- Abstract
- K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of serum-induced arthritis, we injected wild-type and IL-17(-/-) mice with K/BxN serum and evaluated them for signs of arthritis. Unlike wild-type mice, IL-17(-/-) mice did not show any signs of arthritis. IL-17 was produced predominantly by CD3(-) CD4(-) gamma delta TCR- NK1.1(-) Sca1(int) Thy1(hi) cells residing in the inflamed synovial tissue. When synovial cells extracted from normal joints were stimulated with IL-23 or autoantibody-containing immune complexes, a substantial fraction of Sca1(int) Thy1(hi) cells produced IL-17. Thus, we have identified a novel population of IL-17-producing innate synovial cells that play a crucial role in the development of K/BxN serum-induced arthritis.
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