Tricin, a methylated cereal flavone, suppresses fat accumulation by downregulating AKT and mTOR in 3T3-L1 preadipocytes
DC Field | Value | Language |
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dc.contributor.author | Lee, Dabeen | - |
dc.contributor.author | Go, Gwang-Woong | - |
dc.contributor.author | Imm, Jee-Young | - |
dc.date.accessioned | 2022-07-15T05:15:08Z | - |
dc.date.available | 2022-07-15T05:15:08Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153726 | - |
dc.description.abstract | The anti-adipogenic effect of tricin (5, 7, 4'-trihydroxy-3',5'-dimethoxyflavone), a flavone frequently found in cereal crops, and its underlying molecular mechanism were evaluated in 3T3-L1 preadipocytes. Tricin treatment (5–20 µM) significantly inhibited triacylglycerol (TG) accumulation without showing cytotoxicity. The expression of protein kinase B (AKT) was decreased by 80% using 20 µM tricin. The inhibition of mammalian target of rapamycin (mTOR) by tricin led to a significant suppression of the protein levels of CCAAT/enhancer-binding protein alpha (C/EBP-α), peroxisome proliferator-activated receptor gamma (PPAR-γ) and nuclear sterol regulatory element-binding protein 1 (SREBP-1). These results suggest that tricin regulates adipogenesis by targeting the AKT/mTORC1/SREBP-1 pathway in the adipose tissue and it could be used as an anti-obesity agent. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Tricin, a methylated cereal flavone, suppresses fat accumulation by downregulating AKT and mTOR in 3T3-L1 preadipocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Go, Gwang-Woong | - |
dc.identifier.doi | 10.1016/j.jff.2016.08.023 | - |
dc.identifier.scopusid | 2-s2.0-84983559862 | - |
dc.identifier.wosid | 000386193400050 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.26, pp.548 - 556 | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 26 | - |
dc.citation.startPage | 548 | - |
dc.citation.endPage | 556 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | BRAN CONSTITUENT TRICIN | - |
dc.subject.keywordPlus | ACID SYNTHASE | - |
dc.subject.keywordPlus | SREBP ACTIVITY | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordAuthor | Tricin | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | Molecular mechanism | - |
dc.subject.keywordAuthor | 3T3-L1 adipocytes | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1756464616302377?via%3Dihub | - |
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