Effects of repetitive photodynamic therapy using indocyanine green for acne vulgaris
- Authors
- Seo, Hyun Min; Min, Hyung-Geun; Kim, Hee-Joong; Shin, Jong-Hun; Nam, Sang-Ho; Han, Kwang-Soo; Ryu, Joung-Ho; Oh, Jeong-Joon; Kim, Ji Young; Lee, Kwang-Joon; Lee, Seung Jae; Kim, Han-Saem; Kim, Jung-In; Song, Min-Kyu; Kim, Won-Serk
- Issue Date
- Oct-2016
- Publisher
- WILEY-BLACKWELL
- Keywords
- Acne vulgaris; Photodynamic therapy
- Citation
- INTERNATIONAL JOURNAL OF DERMATOLOGY, v.55, no.10, pp.1157 - 1163
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF DERMATOLOGY
- Volume
- 55
- Number
- 10
- Start Page
- 1157
- End Page
- 1163
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153737
- DOI
- 10.1111/ijd.13258
- ISSN
- 0011-9059
- Abstract
- Background: Indocyanine green (ICG) is a photosensitizer recently introduced for the treatment of acne. Objective: To evaluate the efficacy and safety of photodynamic therapy (PDT) using ICG in subjects with acne vulgaris and to evaluate whether there was a difference in the efficacy of ICG-PDT between different numbers of treatment. Materials and methods: Subjects with acne on the face were included. ICG lotion (0.1%) was applied for 30 minutes, and a long pulse diode laser was used. Three or five treatments per subject were performed over 2 weeks. Acne lesion counts and Leeds revised acne grades were evaluated at baseline and 2 weeks after the last treatment. Results: In total, 47 subjects completed the study. After both three and five ICG-PDT sessions, a significant reduction in acne lesions and significant improvement in Leeds revised acne grades were found in all treated subjects compared to baseline. In the subjects receiving five ICG-PDT sessions, the reduction of papules/pustules was greater than in the subjects receiving three ICG-PDT sessions (P < 0.01, respectively). However, there was no significant change in the count of nodules/cysts, although it is a negative trend (P = 0.066). Adverse effects were minimal. Conclusion: ICG-PDT using long-pulsed diode laser can be a safe and effective tool for acne vulgaris. Moreover, repetitive treatments of five can cause further improvement of inflammatory acne lesions.
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