Usefulness of spleen volume measured by computed tomography for predicting clinical outcome in primary myelofibrosis
DC Field | Value | Language |
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dc.contributor.author | Song, Moo-Kon | - |
dc.contributor.author | Chung, Joo-Seop | - |
dc.contributor.author | Lim, Sung-Nam | - |
dc.contributor.author | Lee, Gyeong-won | - |
dc.contributor.author | Lee, Sang-Min | - |
dc.contributor.author | Lee, Nam-Kyung | - |
dc.contributor.author | Choi, Jae-Cheol | - |
dc.contributor.author | Oh, So-Yeon | - |
dc.date.accessioned | 2022-07-15T05:37:49Z | - |
dc.date.available | 2022-07-15T05:37:49Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153869 | - |
dc.description.abstract | Although splenomegaly is major characteristic of primary myelofibrosis (PMF), splenomegaly has been devalued due to a less reliable method based on physical examination (PEx). We evaluated whether spleen volume (SV) on CT would accurately predict clinical outcomes in PMF. A total of 188 patients were enrolled. SV was quantitated by the automatic volume software. In ROC curve, the SV predicted prognosis more accurately than spleen length by PEx (p < 0.001). The ideal cut-off value was 378.1 cm3 for SV, which was divided into high- and low-volume status. Patients with low SV status had superior leukemia-free survival and overall survival compared to high SV status (p < 0.001, p < 0.001) In the Cox analysis, old age ≥65 years (p = 0.004, p = 0.001), low Hemoglobin <10.0 g/dL (p = 0.023, p = 0.021), high WBC counts ≥25 × 109/L (p = 0.003, p = 0.006), peripheral blasts ≥1 % (p = 0.029, p = 0.020), unfavorable cytogenetic abnormalities (p = 0.025, p = 0.028), and high SV status (p = 0.004, p = 0.003) were independently associated with survivals. SV measured by CT was important for predicting survival in patients with PMF. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.title | Usefulness of spleen volume measured by computed tomography for predicting clinical outcome in primary myelofibrosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Moo-Kon | - |
dc.identifier.doi | 10.1007/s12185-016-2050-y | - |
dc.identifier.scopusid | 2-s2.0-84976334740 | - |
dc.identifier.wosid | 000385153200011 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF HEMATOLOGY, v.104, no.4, pp.476 - 484 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF HEMATOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF HEMATOLOGY | - |
dc.citation.volume | 104 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 476 | - |
dc.citation.endPage | 484 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | AGNOGENIC MYELOID METAPLASIA | - |
dc.subject.keywordPlus | CYTOGENETIC-RISK CATEGORIZATION | - |
dc.subject.keywordPlus | INTERNATIONAL WORKING GROUP | - |
dc.subject.keywordPlus | PROGNOSTIC SCORING SYSTEM | - |
dc.subject.keywordPlus | WORLD-HEALTH-ORGANIZATION | - |
dc.subject.keywordPlus | ESSENTIAL THROMBOCYTHEMIA | - |
dc.subject.keywordPlus | IDIOPATHIC MYELOFIBROSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordAuthor | Primary myelofibrosis | - |
dc.subject.keywordAuthor | Splenomegaly | - |
dc.subject.keywordAuthor | Computed tomography | - |
dc.subject.keywordAuthor | Splenic volume | - |
dc.subject.keywordAuthor | Overall survival | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12185-016-2050-y | - |
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