Usefulness of spleen volume measured by computed tomography for predicting clinical outcome in primary myelofibrosis
- Authors
- Song, Moo-Kon; Chung, Joo-Seop; Lim, Sung-Nam; Lee, Gyeong-won; Lee, Sang-Min; Lee, Nam-Kyung; Choi, Jae-Cheol; Oh, So-Yeon
- Issue Date
- Oct-2016
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Primary myelofibrosis; Splenomegaly; Computed tomography; Splenic volume; Overall survival
- Citation
- INTERNATIONAL JOURNAL OF HEMATOLOGY, v.104, no.4, pp.476 - 484
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF HEMATOLOGY
- Volume
- 104
- Number
- 4
- Start Page
- 476
- End Page
- 484
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/153869
- DOI
- 10.1007/s12185-016-2050-y
- ISSN
- 0925-5710
- Abstract
- Although splenomegaly is major characteristic of primary myelofibrosis (PMF), splenomegaly has been devalued due to a less reliable method based on physical examination (PEx). We evaluated whether spleen volume (SV) on CT would accurately predict clinical outcomes in PMF. A total of 188 patients were enrolled. SV was quantitated by the automatic volume software. In ROC curve, the SV predicted prognosis more accurately than spleen length by PEx (p < 0.001). The ideal cut-off value was 378.1 cm3 for SV, which was divided into high- and low-volume status. Patients with low SV status had superior leukemia-free survival and overall survival compared to high SV status (p < 0.001, p < 0.001) In the Cox analysis, old age ≥65 years (p = 0.004, p = 0.001), low Hemoglobin <10.0 g/dL (p = 0.023, p = 0.021), high WBC counts ≥25 × 109/L (p = 0.003, p = 0.006), peripheral blasts ≥1 % (p = 0.029, p = 0.020), unfavorable cytogenetic abnormalities (p = 0.025, p = 0.028), and high SV status (p = 0.004, p = 0.003) were independently associated with survivals. SV measured by CT was important for predicting survival in patients with PMF.
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