Comparative effects of slowly digestible and resistant starch from rice in high-fat diet-induced obese mice

Abstract

The effects of optimized slowly digestible starch (SDS) and resistant starch (RS) from rice starch on weight gain and lipid metabolism in mice (C57BL/6J mice) fed a high-fat diet were investigated. The optimum conditions for SDS were obtained at the pullulanse concentration (X-1) of 498 mu L, storage temperature) (X-2) of 47 degrees C, and A/C cycle (X-3) of 5, and for RS, were determined to be 838 mu L (X-1), 62 degrees C (X-2), and a cycle of 3 (X-3) using response surface methodology (RSM). Mice fed SDS and RS for 6 weeks showed both significantly decreased weight gain and fat pad weight (p<0.05). Significant decrease in total lipid, triglyceride, and cholesterol concentrations in serum and liver was observed in both SDS and RS group compared to HFD groups (p<0.05). Although both of intake SDS and RS significantly contributed to beneficial effects, RS groups was more effective than SDS group in all parameters.