TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Canceropen access
- Authors
- Myung, Jae Kyung; Kwak, Byung Kuk; Lim, Jung Ah; Lee, Myung-Chul; Kim, Min Joo
- Issue Date
- Jul-2016
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Papillary thyroid cancer; Telomerase; Thyroid neoplasms
- Citation
- CANCER RESEARCH AND TREATMENT, v.48, no.3, pp.942 - 947
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 48
- Number
- 3
- Start Page
- 942
- End Page
- 947
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154275
- DOI
- 10.4143/crt.2015.362
- ISSN
- 1598-2998
- Abstract
- Purpose
A telomerase reverse transcriptase (TERT) promoter mutation was identified in thyroid cancer. This TERT promoter mutation is thought to be a prognostic molecular marker, because its association with tumor aggressiveness, persistence/recurrence, and disease-specific mortality in papillary thyroid carcinoma (PTC) has been reported. In this study, we attempted to determine whether the impact of the TERT promoter mutation on PTC persistence/recurrence is independent of clinicopathological parameters.
Materials and Methods
Using propensity score matching, 39 patients with PTC persistence or recurrence were matched with 35 patients without persistence or recurrence, with a similar age, sex, tumor size, multifocality, bilaterality, extrathyroidal extension, and lymph node metastasis. The TERT promoter and the BRAF V600E mutations were identified from PTC samples.
Results
The TERT promoter mutation was detected in 18% of PTC patients (13/74). No significant difference in the frequency of the TERT promoter mutation was observed between the persistence/recurrence group and the non-recurrence group.
Conclusion
These results suggest that the prognostic implications of the TERT promoter mutation are dependent on clinicopathological parameters.
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