Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine-fructoseopen access
- Authors
- Lee, Kyung Hee; Bae, In Young; Park, Song I.; Park, Jong-Dae; Lee, Hyeon Gyu
- Issue Date
- Jul-2016
- Publisher
- KOREAN SOC GINSENG
- Keywords
- arginine-fructose; blood pressure; ginsenoside Rg3; hypotensive components-enriched; Korean Red Ginseng
- Citation
- JOURNAL OF GINSENG RESEARCH, v.40, no.3, pp.237 - 244
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 40
- Number
- 3
- Start Page
- 237
- End Page
- 244
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154312
- DOI
- 10.1016/j.jgr.2015.08.002
- ISSN
- 1226-8453
- Abstract
- Background
Ginsenoside Rg3 and arginine–fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng; however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from fine root concentrate (FR) and their antihypertensive effects were investigated in spontaneously hypertensive rats (SHR).
Methods
Male SHRs were divided into six groups: control (Wistar Kyoto, SHR); FR 500; FR 1,000; HCEF-RG 500; and HCEF-RG 1,000; samples (mg/kg body weight) were orally administered every day for 8 wk. Blood pressure was monitored at 1 wk, 2 wk, 3 wk, 4 wk, 6 wk, and 8 wk by tail cuff method. At 8 wk after samples administration, mice were killed for the measurement of renin activity (RA), angiotensin-I converting enzyme inhibition, angiotensin II, and nitric oxide (NO) levels in plasma.
Results
HCEF-RG with four-fold more Rg3 and 24-fold more Arg-Fru contents was successfully prepared from reacted mixtures of FR and persimmon vinegar (12 times against FR, v/v) at 80°C for 18 h. Both FR 1,000 and HCEF-RG 1,000 showed lowered systolic blood pressure than SHR control group and HCEF-RG 1,000 group exhibited a significant decrease in diastolic blood pressure. RA was significantly lowered in all treated groups, while angiotensin II did not affect by FR and HCEF-RG treatment. However, angiotensin-I converting enzyme inhibition and NO in FR 1,000 and HCEF-RG 1,000 were significantly increased compared with SHR control group.
Conclusion
HCEF-RG is more effective and useful for alleviating hypertension than FR, implying the health benefit of Rg3 and Arg-Fru.
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