Nanoencapsulation of Red Ginseng Extracts Using Chitosan with Polyglutamic Acid or Fucoidan for Improving Antithrombotic Activities
- Authors
- Kim, Eun Suh; Lee, Ji-Soo; Lee, Hyeon Gyu
- Issue Date
- Jun-2016
- Publisher
- AMER CHEMICAL SOC
- Keywords
- red ginseng extracts; chitosan nanoparticles; ionic gelation; platelet aggregation; antithrombotic activity
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.23, pp.4765 - 4771
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 64
- Number
- 23
- Start Page
- 4765
- End Page
- 4771
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/154532
- DOI
- 10.1021/acs.jafc.6b00911
- ISSN
- 0021-8561
- Abstract
- The potential of nanoencapsulation using bioactive coating materials for improving antithrombotic activities of red ginseng extract (RG) was examined. RG-loaded chitosan (CS) nanoparticles were prepared using antithrombotic materials, polyglutamic acid (PGA) or fucoidan (Fu). Both CS–PGA (P-NPs, 360 ± 67 nm) and CS–Fu nanoparticles (F-NPs, 440 ± 44 nm) showed sustained ginsenoside release in an acidic environment and improved ginsenoside solubility by approximately 122.8%. Both in vitro rabbit and ex vivo rat platelet aggregation of RG (22.3 and 41.5%) were significantly (p < 0.05) decreased within P-NPs (14.4 and 30.0%) and F-NPs (12.3 and 30.3%), respectively. Although RG exhibited no effect on in vivo carrageenan-induced mouse tail thrombosis, P-NPs and F-NPs demonstrated significant effects, likely the anticoagulation activity of PGA and Fu. Moreover, in the in vivo rat arteriovenous shunt model, P-NPs (156 ± 6.8 mg) and F-NPs (160 ± 3.2 mg) groups showed significantly lower thrombus formation than that of RG (190 ± 5.5 mg). Therefore, nanoencapsulation using CS, PGA, and Fu is a potential for improving the antithrombotic activity of RG.
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