Gray and white matter changes linking cerebral small vessel disease to gait disturbances
- Authors
- Kim, Yeo Jin; Kwon, Hun Ki; Lee, Jong Min; Cho, Hanna; Kim, Hee Jin; Park, Hee Kyung; Jung, Na-Yeon; Lee, Jin San; Lee, Juyoun; Jang, Young Kyoung; Kim, Sung Tae; Lee, Kyung Han; Choe, Yearn Seong; Kim, Yun Joong; Na, Duk L.; Seo, Sang Won
- Issue Date
- Mar-2016
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Citation
- NEUROLOGY, v.86, no.13, pp.1199 - 1207
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROLOGY
- Volume
- 86
- Number
- 13
- Start Page
- 1199
- End Page
- 1207
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155047
- DOI
- 10.1212/WNL.0000000000002516
- ISSN
- 0028-3878
- Abstract
- Objective: To investigate the topographic changes of white matter (WM) integrity and cortical thickness related to gait disturbances and determine whether these neural correlates mediate the association between cerebral small vessel disease (CSVD) and gait disturbances. Methods: A total of 129 patients with subcortical vascular cognitive impairment were included. CSVD severity was quantified as global and regional WM hyperintensities (WMH) volume and lacune and microbleed numbers. Amyloid burdens were assessed using Pittsburgh compound B (PiB)-PET scanning. Gait score was measured using a standardized scale. WM integrity was assessed by applying tract-based spatial statistics. Cortical thickness was measured using surface-based methods. Path analysis for gait score was performed using regional CSVD markers as predictors and fractional anisotropy (FA) and cortical thickness as mediators. Results: Periventricular WMH (PWMH) volume was associated with gait score, regardless of other CSVD. PiB retention ratio was not associated with gait score. Gait score was correlated with FA in the frontal and parietal WM and bilateral corpus callosum and with cortical thinning in the bilateral frontal and lateral temporo-parieto-occipital regions. Path analysis for gait score showed that PWMH contributed to gait disturbances with the mediation of mean FA or cortical thickness. Conclusions: Our findings suggest that WMH-related cortical thinning as well as disrupted integrity of periventricular WM is linked to gait disturbances.
- Files in This Item
-
Go to Link
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.