A Case of Teicoplanin-Induced Pancytopenia Caused by Excessive Dosing
- Authors
- Choi, Hye Min; Choi, Moon Hee; Yang, Yoo Whooi
- Issue Date
- Feb-2016
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- adverse drug reaction; pancytopenia; teicoplanin
- Citation
- AMERICAN JOURNAL OF THERAPEUTICS, v.23, no.1, pp.e307 - e310
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF THERAPEUTICS
- Volume
- 23
- Number
- 1
- Start Page
- e307
- End Page
- e310
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155108
- DOI
- 10.1097/MJT.0000000000000008
- ISSN
- 1075-2765
- Abstract
- Teicoplanin is reported to be as effective as vancomycin but with minimal side effects. We report a case of teicoplanin-induced pancytopenia, which has not been demonstrated previously. A 44-year-old man with tetraplegia was treated with a diagnosis of urinary tract infection and pneumonia, and a high-dose of teicoplanin (400 mg every 12 hours) was administered for 4 days inadvertently. Although the infection rapidly improved, the patient developed pancytopenia by the fourth day of teicoplanin therapy, which was improved after reducing the dose of teicoplanin (200 mg/d). Our patient represents a probable case of teicoplanin-induced pancytopenia with adverse drug reaction probability score of 6.
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