Association between diabetes mellitus and oncological outcomes in bladder cancer patients undergoing radical cystectomy
- Authors
- Oh, Jong Jin; Kang, Min Yong; Jo, Jung Ki; Lee, Hak Min; Byun, Seok-Soo; Lee, Sang Eun; Lee, Sangchul; Hong, Sung Kyu
- Issue Date
- Dec-2015
- Publisher
- WILEY-BLACKWELL
- Keywords
- bladder; bladder cancer; diabetes mellitus; radical cystectomy; survival
- Citation
- INTERNATIONAL JOURNAL OF UROLOGY, v.22, no.12, pp.1112 - 1117
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF UROLOGY
- Volume
- 22
- Number
- 12
- Start Page
- 1112
- End Page
- 1117
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155585
- DOI
- 10.1111/iju.12901
- ISSN
- 0919-8172
- Abstract
- Objective: To determine the association between diabetes mellitus and oncological outcomes in urothelial bladder cancer patients undergoing radical cystectomy.
Methods: From January 2004 to December 2014, 200 non-metastatic urothelial bladder cancer patients who underwent radical cystectomy were divided into two groups according to diabetes mellitus status at the time of surgery. Kaplan-Meier and Cox regression analysis were used to assess the association between diabetes mellitus and urothelial bladder cancer recurrence-free, cancer-specific and overall mortality.
Results: Of the 200 patients, 28 (14%) had diabetes mellitus and presented similar preoperative factors and pathological findings after radical cystectomy, including pathological stage, grade, lymph node invasion and positive surgical margin compared with non-diabetes mellitus patients (n = 172). The 5-year cancer-specific survivals were 92.3% and 62.1% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P = 0.022). Multivariate Cox regression analysis showed that diabetes mellitus was a significant predictor for cancer-specific mortality (hazard ratio 1.785, P = 0.038). The 5-year overall survival rate was 92.1% and 59.4% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P = 0.014), and diabetes mellitus was a significant factor for overall mortality by multivariate Cox regression analysis (hazard ratio 1.281, P = 0.042).
Conclusions: Among bladder cancer patients who underwent radical cystectomy, the diabetes mellitus patients had worse cancer-specific mortality and overall mortality outcomes than the non-diabetes mellitus patients. The mechanism of association between diabetes mellitus and urothelial bladder cancer should be investigated to validate the present results in a future prospective study.
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