High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | Sim, Jongmin | - |
dc.contributor.author | Ahn, Hyein | - |
dc.contributor.author | Abdul, Rehman | - |
dc.contributor.author | Kim, Hyunsung | - |
dc.contributor.author | Yi, Ki-jong | - |
dc.contributor.author | Chung, Yu-min | - |
dc.contributor.author | Chung, Min Sung | - |
dc.contributor.author | Paik, Seung Sam | - |
dc.contributor.author | Song, Young Soo | - |
dc.contributor.author | Jang, Kiseok | - |
dc.date.accessioned | 2022-07-15T19:56:48Z | - |
dc.date.available | 2022-07-15T19:56:48Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1738-6756 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155689 | - |
dc.description.abstract | Purpose: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. Methods: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome. Results: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression. Conclusion: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN BREAST CANCER SOC | - |
dc.title | High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, Min Sung | - |
dc.contributor.affiliatedAuthor | Paik, Seung Sam | - |
dc.contributor.affiliatedAuthor | Jang, Kiseok | - |
dc.identifier.doi | 10.4048/jbc.2015.18.4.323 | - |
dc.identifier.scopusid | 2-s2.0-84957623588 | - |
dc.identifier.wosid | 000367490100003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BREAST CANCER, v.18, no.4, pp.323 - 328 | - |
dc.relation.isPartOf | JOURNAL OF BREAST CANCER | - |
dc.citation.title | JOURNAL OF BREAST CANCER | - |
dc.citation.volume | 18 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 323 | - |
dc.citation.endPage | 328 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002063453 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | MIR-370 | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SAMPLES | - |
dc.subject.keywordPlus | FOXM1 | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | SIGNATURES | - |
dc.subject.keywordAuthor | Breast neoplasms | - |
dc.subject.keywordAuthor | MicroRNA-370 | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Real-time polymerase chain reaction | - |
dc.identifier.url | https://ejbc.kr/DOIx.php?id=10.4048/jbc.2015.18.4.323 | - |
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