High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Canceropen access
- Authors
- Sim, Jongmin; Ahn, Hyein; Abdul, Rehman; Kim, Hyunsung; Yi, Ki-jong; Chung, Yu-min; Chung, Min Sung; Paik, Seung Sam; Song, Young Soo; Jang, Kiseok
- Issue Date
- Dec-2015
- Publisher
- KOREAN BREAST CANCER SOC
- Keywords
- Breast neoplasms; MicroRNA-370; Prognosis; Real-time polymerase chain reaction
- Citation
- JOURNAL OF BREAST CANCER, v.18, no.4, pp.323 - 328
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF BREAST CANCER
- Volume
- 18
- Number
- 4
- Start Page
- 323
- End Page
- 328
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155689
- DOI
- 10.4048/jbc.2015.18.4.323
- ISSN
- 1738-6756
- Abstract
- Purpose: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. Methods: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome. Results: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression. Conclusion: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes.
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