PLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Joo-Hwa | - |
dc.contributor.author | Choi, Hye-Jin | - |
dc.contributor.author | Oh, Cheong-Hae | - |
dc.contributor.author | Oh, Jae-Won | - |
dc.contributor.author | Han, Joong-Soo | - |
dc.date.accessioned | 2022-07-15T20:26:18Z | - |
dc.date.available | 2022-07-15T20:26:18Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156039 | - |
dc.description.abstract | The purpose of this study was to identify the role of phospholipase D1 (PLD1) in Amb a 1-induced IL-5 and IL-13 expression. When BEAS-2B cells were stimulated with Amb a 1, PLD activity increased, and knockdown of PLD1 decreased Amb a 1-induced IL-5 and IL-13 expression. Amb a 1 also activated the PLC gamma/p70S6K/JNK pathway. Furthermore, Amb a 1-induced PLD activation was also attenuated by PLC gamma inhibition, and knockdown of PLD1 decreased Amb a 1-induced activation of P70S6K and JNK. When ATF-2 activity was blocked with ATF-2 siRNA, Amb a 1-induced IL-5 and IL-13 expression was completely abolished, indicating that ATF-2 is a transcriptional factor required for the expression of IL-5 and IL-13 in response to Amb a 1. Taken together, we suggest that PLD1 acts as an important regulator in Amb a 1-induced expression of IL-5 and IL-13 via a PLC gamma/p70S6K/JNK/ATF-2 pathway in BEAS-2B cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | PLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Jae-Won | - |
dc.contributor.affiliatedAuthor | Han, Joong-Soo | - |
dc.identifier.doi | 10.1016/j.cellimm.2015.08.003 | - |
dc.identifier.scopusid | 2-s2.0-84958541513 | - |
dc.identifier.wosid | 000369168400002 | - |
dc.identifier.bibliographicCitation | CELLULAR IMMUNOLOGY, v.298, no.1-2, pp.9 - 17 | - |
dc.relation.isPartOf | CELLULAR IMMUNOLOGY | - |
dc.citation.title | CELLULAR IMMUNOLOGY | - |
dc.citation.volume | 298 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHESIS | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | P70 S6 KINASE | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-D | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | RAGWEED | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MTOR | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordAuthor | Ambrosia artemisiifolia | - |
dc.subject.keywordAuthor | PLD1 | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | p70S6K | - |
dc.subject.keywordAuthor | IL-13 | - |
dc.subject.keywordAuthor | IL-5 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0008874915300095?via%3Dihub | - |
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