PLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cells
- Authors
- Kim, Joo-Hwa; Choi, Hye-Jin; Oh, Cheong-Hae; Oh, Jae-Won; Han, Joong-Soo
- Issue Date
- Nov-2015
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Ambrosia artemisiifolia; PLD1; JNK; p70S6K; IL-13; IL-5
- Citation
- CELLULAR IMMUNOLOGY, v.298, no.1-2, pp.9 - 17
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLULAR IMMUNOLOGY
- Volume
- 298
- Number
- 1-2
- Start Page
- 9
- End Page
- 17
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156039
- DOI
- 10.1016/j.cellimm.2015.08.003
- ISSN
- 0008-8749
- Abstract
- The purpose of this study was to identify the role of phospholipase D1 (PLD1) in Amb a 1-induced IL-5 and IL-13 expression. When BEAS-2B cells were stimulated with Amb a 1, PLD activity increased, and knockdown of PLD1 decreased Amb a 1-induced IL-5 and IL-13 expression. Amb a 1 also activated the PLC gamma/p70S6K/JNK pathway. Furthermore, Amb a 1-induced PLD activation was also attenuated by PLC gamma inhibition, and knockdown of PLD1 decreased Amb a 1-induced activation of P70S6K and JNK. When ATF-2 activity was blocked with ATF-2 siRNA, Amb a 1-induced IL-5 and IL-13 expression was completely abolished, indicating that ATF-2 is a transcriptional factor required for the expression of IL-5 and IL-13 in response to Amb a 1. Taken together, we suggest that PLD1 acts as an important regulator in Amb a 1-induced expression of IL-5 and IL-13 via a PLC gamma/p70S6K/JNK/ATF-2 pathway in BEAS-2B cells.
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