Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat
- Authors
- Kim, Kyung-Soo; Song, Yi-Sun; Jin, Jiyong; Joe, Jun-Ho; So, Byung-Im; Park, Jun-Young; Fang, Cheng-Hu; Kim, Mi Jung; Cho, Youl-Hee; Hwang, Sejin; Ro, Young-Suck; Kim, Hyuck; Ahn, You-Hem; Sung, Hak-Joon; Sung, Jung-Joon; Park, Sung-Hye; Lipton, Stuart A.
- Issue Date
- Oct-2015
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Diabetic neuropathy; Granulocyte-colony stimulating factor; Bone marrow-derived cells
- Citation
- MOLECULAR AND CELLULAR ENDOCRINOLOGY, v.414, pp.64 - 72
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Volume
- 414
- Start Page
- 64
- End Page
- 72
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156314
- DOI
- 10.1016/j.mce.2015.07.014
- ISSN
- 0303-7207
- Abstract
- Effective treatment of diabetic neuropathy (DN) remains unsolved. We serendipitously observed dramatic relief of pain in several patients with painful DN receiving granulocyte-colony stimulating factor (G-CSF). The aim of this study was to determine if G-CSF could treat DN in an animal model and to ascertain its mechanism of action. In a rodent model of DN, G-CSF dramatically recovered nerve function, retarded histological nerve changes and increased the expression of neurotrophic factors within nerve. A sex-mismatched bone marrow transplantation (BMT) study revealed that G-CSF treatment increased the abundance of bone marrow (BM)-derived cells in nerves damaged by DN. However, we did not observe evidence of transdifferentiation or cell fusion of BM-derived cells. The beneficial effects of G-CSF were dependent on the integrity of BM. In conclusion, G-CSF produced a therapeutic effect in a rodent model of DN, which was attributed, at least in part, to the actions of BM-derived cells.
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