The relationship between brain-derived neurotrophic factor and cognitive functions in alcohol-dependent patients: a preliminary studyopen access
- Authors
- Han, Changwoo; Bae, Hwallip; Won, Sung-Doo; Roh, Sung won; Kim, Dai-Jin
- Issue Date
- Sep-2015
- Publisher
- BIOMED CENTRAL LTD
- Keywords
- Alcohol dependence; Cognitive function; Brain-derived neurotrophic factor
- Citation
- ANNALS OF GENERAL PSYCHIATRY, v.14, no.1, pp.1 - 10
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- ANNALS OF GENERAL PSYCHIATRY
- Volume
- 14
- Number
- 1
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156316
- DOI
- 10.1186/s12991-015-0065-z
- ISSN
- 1744-859X
- Abstract
- Background: As a neurotoxic substance, alcohol can induce neurodegenesis in the brain. Alcohol-dependent patients' cognitive functioning can be affected by chronic alcohol use. In addition, brain-derived neurotrophic factor (BDNF) is known to reflect the status of neuroadaptive changes. The purpose of this study was to investigate the relationship between cognitive functions and BDNF in alcohol-dependent patients.
Methods: The subjects were 39 alcohol-dependent patients. BDNF was measured using an enzyme-linked immunosorbent assay kit. We examined clinical features and administered the Korean version of Alcohol Dependence Scale. We also used the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) to measure cognitive functioning. Then, we determined the relationships between BDNF and various parts of the CERAD.
Results: The performance of alcohol-dependent patients proved stable in most parts of the CERAD. Within the different parts of the CERAD, only Trail Making Test B correlated with BDNF. Trail Making Test specifically assesses executive functions.
Conclusions: BDNF might play an important role in the detection of neurocognitive function among individuals with alcohol dependence.
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