Serum Ferritin Predicts Mortality Regardless of Inflammatory and Nutritional Status in Patients Starting Dialysis: A Prospective Cohort Study
- Authors
- Park, Kyoung Sook; Ryu, Geun Woo; Jhee, Jong Hyun; Kim, Hyung Woo; Park, Seohyun); Lee, Sul A.; Kwon, Young Eun; Kim, Yung Ly; Ryu, Han Jak; Lee, Mi Jung; Han, Seung Hyeok; Yoo, Tae-Hyun; Kim, Yong-Lim; Kim, Yon Su; Yang, Chul Woo; Kim, Nam-Ho; Kang, Shin-Wook; Park, Jung Tak
- Issue Date
- Sep-2015
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- Clinical outcome; End-stage renal disease; Ferritin; Hemodialysis
- Citation
- MEDICINE, v.40, no.3, pp.209 - 217
- Indexed
- SCIE
SCOPUS
- Journal Title
- MEDICINE
- Volume
- 40
- Number
- 3
- Start Page
- 209
- End Page
- 217
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156353
- DOI
- 10.1159/000438819
- ISSN
- 0025-7974
- Abstract
- Background: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. Methods: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. Results: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). Conclusion: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.
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