대기 미세먼지가 천식 발생과 조절에 미치는 영향Effects of particulate matter in ambient air on the development and control of asthma
- Other Titles
- Effects of particulate matter in ambient air on the development and control of asthma
- Authors
- Kim, Sang-Heon; Yang, Hyeon-Jong; Jang, An-Soo; Kim, Sang-Hoon; Song, Woo-Jung; Kim, Tae-Bum; Ye, Young-Min; Yoo, Young; Yu, Jinho; Yoon, Jong-Seo; Jee, Hye Mi; Suh, Dong In; Kim, Cheol-Woo
- Issue Date
- Sep-2015
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Particulate matter; Asthma; Disease progression; Disease susceptibility
- Citation
- ALLERGY ASTHMA & RESPIRATORY DISEASE, v.3, no.5, pp.313 - 319
- Indexed
- KCI
- Journal Title
- ALLERGY ASTHMA & RESPIRATORY DISEASE
- Volume
- 3
- Number
- 5
- Start Page
- 313
- End Page
- 319
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156468
- DOI
- 10.4168/aard.2015.3.5.313
- ISSN
- 2288-0402
- Abstract
- There has been growing concern regarding the effects of ambient air pollution on asthma. Particulate matter (PM) is one of the major air pollutants affecting both general population and the patients with asthma. This paper reviews the recent evidence of the adverse effects of PM on the inception and morbidity of asthma. Epidemiological studies confirmed that short-term exposure to PM aggravated respiratory symptoms and lung function in asthma patients. Furthermore, PM induces acute exacerbations of asthma with increased risk of hospitalization and death. Long-term exposure to PM is responsible for new onset of asthma and lung function decline in both children and adults. Various mechanisms are involved in the effects of PM on airway including oxidative stress, augmentation of inflammation, promotion of allergen sensitization, induction of airway hyperresponsiveness, aggravation of rhinitis and DNA methylation. Special attention and care is needed for the patients with asthma to prevent the detrimental effects of PM.
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