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소아천식 환자에서 충격진동법과 폐활량기로 측정한 소기도 장애와 호기산화질소와의 관계open accessRelationship between exhaled nitric oxide and small-airway dysfunction in children with asthma using spirometry and the impulse oscillometry system

Other Titles
Relationship between exhaled nitric oxide and small-airway dysfunction in children with asthma using spirometry and the impulse oscillometry system
Authors
서보선이정민조은혜백지현이경석신윤호지혜미정영호한만용
Issue Date
Jul-2015
Publisher
대한 소아알레르기 호흡기학회/대한천식알레르기학회
Keywords
Asthma; Nitric oxide; Respiratory function tests; Spirometry; Arway resistance
Citation
Allergy Asthma & Respiratory Disease, v.3, no.4, pp.267 - 271
Indexed
KCI
Journal Title
Allergy Asthma & Respiratory Disease
Volume
3
Number
4
Start Page
267
End Page
271
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156768
DOI
10.4168/aard.2015.3.4.267
ISSN
2288-0402
Abstract
Purpose: Fractional exhaled nitric oxide (FeNO) is a maker of airway inflammation, and impedance of low frequency in the impulse oscillometry system (IOS) reflects small-airway obstruction. We investigated the association of the FeNO level with IOS parameters and spirometry results in asthma patients. Methods: Fifty-eight children with asthma (60.3%, male), mean age 8.3 years (range, 4.5–16.0 years), were enrolled in the study. Reactance and resistance at 5 Hz with IOS, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and forced expiratory flow 25%–75% of the vital capacity (FEF25%-75%) with spirometry and FeNO were measured in all patients. The Z-score of spirometry and IOS parameters and the mean level of FeNO were used for correlation and regression analysis. Results: FeNO was not significantly associated with height, age, or other demographic parameters. There was a statistically significant correlation between spirometry results and IOS measurements. The FeNO level was not significantly correlated with IOS variables. After adjusting for height, sex, atopic status, and the use of inhaled corticosteroid, the FeNO level showed significant correlations with Z-score of FEV1/FVC (P=0.037, adjusted R2=0.234). Conclusion: FeNO was significantly correlated with Z-scores of FEV1/FVC, but not with IOS variables. Therefore, FeNO may be used to detect whole airway obstruction, but not small-airway obstruction.
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서울 의과대학 > 서울 소아청소년과학교실 > 1. Journal Articles

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